Professor Arshad Majid
School of Medicine and Population Health
Professor of Cerebrovascular Neurology
Consultant Neurologist, Royal Hallamshire Hospital
Chief Investigator, TRICEPS Trial (NIHR EME · Association of British Neurologists · Stroke Association)
Co Chief Investigator, RICFAST Trial (Stroke Association)


+44 114 222 2290
Full contact details
School of Medicine and Population Health
΢ÃÜȦ Institute for Translational Neuroscience (SITraN)
385a Glossop Road
΢ÃÜȦ
S10 2HQ
- Profile
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My professional mission is to translate cutting‑edge neuroscience into effective therapies for patients with cerebrovascular and other neurological diseases. Following medical graduation from the University of Glasgow, specialist training in Neurology at the University of Pennsylvania, and fellowship training at Washington University in St Louis and the Medical College of Wisconsin, I have pursued a career that bridges bench science and bedside care.
I am honoured to hold the title of NIHR Senior Investigator and to lead major UK multicentre trials:
- TRICEPS (TRanscutaneous Vagus Nerve Stimulation to enhance limb rECovery PoSt‑Stroke) – evaluating whether pairing task‑specific upper‑limb rehabilitation with movement‑activated transcutaneous vagus nerve stimulation improves arm function after stroke.
- RICFAST (Remote Ischaemic Conditioning For fATigue after STroke) – investigating whether repeated brief episodes of limb ischaemia and reperfusion can reduce debilitating post‑stroke fatigue.
Previously I founded the Division of Cerebrovascular Diseases at Michigan State University and the William & Claire Dart Stroke Center at Sparrow Health System before joining the University of ΢ÃÜȦ and Royal Hallamshire Hospital in 2013.
I serve as Director of the Comprehensive Cerebrovascular Research Unit (CCRU). My research has been funded by the NIH, American Heart Association, MRC, NIHR and industry.
- Research interests
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Key research areas:
- Neuroprotection and Neuroregeneration
- Electroceuticals
- Stroke Clinical Trials,
- Animal and Cellular Models of Stroke and Neuroinflammation
- Novel Drug Delivery (nanotechnology and exosomes)
- Remote Conditioning, Vagus Nerve Stimulation.
- Gene editing, gene blocking & gene replacement for hereditary cerebral small‑vessel diseases — including vascular dementia, COL4A1/COL4A2 mutation‑related angiopathy and CADASIL
Trial / Project Role Focus TRICEPS Chief Investigator Movement-activated tVNS paired with upper-limb rehab to improve arm recovery post-stroke RICFAST Co-Chief Investigator RIC as a home-based intervention for alleviating post-stroke fatigue Gene-block & replacement therapy Principal Investigator CRISPR/Cas-based editing and AAV-mediated replacement for COL4A1/2 disease, CADASIL & vascular dementia Stroke vaccine development Lead Immunomodulatory vaccine to mitigate secondary neuroinflammation after stroke Donations
Help Us Beat Rare Genetic Stroke Disorders
Vascular dementia, CADASIL, and COL4A1/2-related diseases are often inherited, progressive, and devastating. These disorders can cause strokes, cognitive decline, and long-term disability in both children and adults.
No disease-modifying treatments currently exist. Our lab is developing world-first gene-block and gene-replacement therapies that offer real hope to affected families. Traditional research funding often overlooks rare conditions, making philanthropic support absolutely vital to accelerate these breakthroughs.
How You Can Help
- Fund a PhD student or postdoc working on CADASIL or COL4A1 therapy
- Support development of gene therapy vectors for testing in preclinical models
- Sponsor patient registries and biobank infrastructure
- Partner with us to launch early-phase clinical trials
If you or your organisation would like to make a contribution or explore partnership opportunities, please email me directly at arshad.majid@sheffield.ac.uk.
Every contribution, large or small, drives innovation and hope for people affected by genetic stroke disorders.
- Publications
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Edited books
Journal articles
Chapters
Conference proceedings papers
Preprints
- Research group
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Doctoral Students
Professor Majid welcomes enquiries from students interested in pursuing a doctorate in translational and clinical research. Several projects, preclinical (translational) and clinical are available. These include development of vaccines for neurological diseases, remote conditioning, development of exosome technologies for therapeutics and development of novel neurotherapeutics.
Post-Doctoral Scientists (short and long-term):
Several preclinical and clinical projects are available.
- Teaching activities
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Professor Majid is the Phase 3a Neurology Lead for ΢ÃÜȦ Medical school.