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Journal articles

• Xia Z, Prescott EE, Urbanek A, Wareing HE, King MC, Olerinyova A, Dakin H, Leah T, Barnes KA, Matuszyk MM , Dimou E et al (2024) . Nature Communications, 15.
• Mistry H, Richardson CD, Higginbottom A, Ashford B, Ahamed SU, Moore Z, Matthews FE, Brayne C, Simpson JE & Wharton SB (2024) . Neuroscience Research, 204, 22-33.
• Castelli LM, Lin Y-H, Sanchez-Martinez A, Gül A, Imran KM, Higginbottom A, Márkus NM, Upadhyay SK, Martins AW, Cooper-Knock J , Montmasson C et al (2023) . Science Translational Medicine, 15(685).
• Giovannelli I, Higginbottom A, Kirby J, Azzouz M & Shaw PJ (2023) . Nature Reviews Neurology, 19(1), 39-52.
• Bauer CS, Webster CP, Shaw AC, Kok JR, Castelli LM, Lin Y-H, Smith EF, Illanes-Álvarez F, Higginbottom A, Shaw PJ , Azzouz M et al (2022) . Frontiers in Cellular Neuroscience, 16.
• Marrone L, Marchi PM, Webster CP, Marroccella R, Coldicott I, Reynolds S, Alves-Cruzeiro J, Yang Z-L, Higginbottom A, Khundadze M , Shaw PJ et al (2022) . Human Molecular Genetics.
• Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N , Dadosh T et al (2020) . Molecular Cell, 80(5), 876-891.e6.
• Lorente Pons A, Higginbottom A, Cooper‐Knock J, Alrafiah A, Alofi E, Kirby J, Shaw PJ, Wood JD & Highley JR (2020) . The Journal of Pathology.
• Allen S, Hall B, Castelli L, Frances L, Woof R, Siskos A, Kouloura E, Gray E, Thompson A, Talbot K , Higginbottom A et al (2019) . Brain, 142(3), 586-605.
• Cooper-Knock J, Moll T, Ramesh T, Castelli L, Beer A, Robins H, Fox I, Niedermoser I, Van Damme P, Moisse M , Robberecht W et al (2019) . Cell Reports, 26(9), 2298-2306.e5.
• Shaw MP, Higginbottom A, Mcgown A, Castelli LM, James E, Hautbergue GM, Shaw PJ & Ramesh TM (2018) . Acta Neuropathologica Communications, 6(1).
• Iannitti T, Scarrott J, Likhite S, Coldicott IRP, Lewis KE, Heath PR, Higginbottom A, Myszczynska MA, Milo M, Hautbergue GM , Meyer K et al (2018) . Molecular Therapy : Nucleic Acids, 12, 75-88.
• Vogt MA, Ehsaei Z, Knuckles P, Higginbottom A, Helmbrecht MS, Kunath T, Eggan K, Williams LA, Shaw PJ, Wurst W , Floss T et al (2018) . Scientific Reports, 8(1).
• Cooper-Knock J, Robins H, Niedermoser I, Wyles M, Heath PR, Higginbottom A, Walsh T, Kazoka M, Ince PG, Hautbergue GM , McDermott CJ et al (2017) . Frontiers in Molecular Neuroscience, 10, 370-370.
• Walker C, Herranz-Martin S, Karyka E, Liao C, Lewis K, Lukashchuk V, Chiang S-C, Ray S, Mulcahy PJ, Jurga M , Tsagakis I et al (2017) . Nature Neuroscience, 20, 1225-1235.
• Hautbergue GM, Castelli LM, Ferraiuolo L, Sanchez-Martinez A, Cooper-Knock J, Higginbottom A, Lin YH, Bauer CS, Dodd JE, myszczynska MA , Alam SM et al (2017) . Nature Communications, 8.
• Herranz-Martin S, Chandran J, Lewis K, Mulcahy P, Higginbottom A, Walker C, Valenzuela IM-PY, Jones RA, Coldicott I, Iannitti T , Akaaboune M et al (2017) . Disease Models & Mechanisms, 10, 859-868.
• Stopford M, Higginbottom A, Hautbergue , Cooper-Knock , Mulcahy , De Vos K, Renton A, Pliner H, Calvo A, Chio A , Traynor B et al (2017) . Human Molecular Genetics, 26(6), 1133-1145.
• Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ , Kaspar BK et al (2016) . EMBO Journal, 35(15), 1656-1676.
• Bury JJ, Highley JR, Cooper‐Knock J, Goodall EF, Higginbottom A, McDermott CJ, Ince PG, Shaw PJ & Kirby J (2016) . Neuropathology, 36(2), 125-134.
• Cooper-Knock J, Higginbottom A, Stopford MJ, Highley JR, Ince PG, Wharton SB, Pickering-Brown S, Kirby J, Hautbergue GM & Shaw PJ (2015) . Acta Neuropathologica, 130(1), 63-75.
• Simpson JE, Ince PG, Matthews FE, Shaw PJ, Heath PR, Brayne C, Garwood C, Higginbottom A & Wharton SB (2015) . Neuropathology and Applied Neurobiology, 41(4), 483-496.
• Cooper-Knock J, Bury JJ, Heath PR, Wyles M, Higginbottom A, Gelsthorpe C, Highley JR, Hautbergue G, Rattray M, Kirby J & Shaw PJ (2015) . PLOS ONE, 10(5), e0127376-e0127376.
• Beer AM, Cooper-Knock J, Higginbottom A, Highley JR, Wharton SB, Ince PG, Milano A, Jones AA, Al-Chalabi A, Kirby J & Shaw PJ (2015) . Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16(3-4), 249-251.
• Hulme RS, Higginbottom A, Palmer J, Partridge LJ & Monk PN (2014) . PLoS ONE, 9(12).
• Highley JR, Kirby J, Jansweijer JA, Webb PS, Hewamadduma CA, Heath PR, Higginbottom A, Raman R, Ferraiuolo L, Cooper-Knock J , McDermott CJ et al (2014) . Neuropathology and Applied Neurobiology, 40(6), 670-685.
• Cooper-Knock J, Walsh MJ, Higginbottom A, Robin Highley J, Dickman MJ, Edbauer D, Ince PG, Wharton SB, Wilson SA, Kirby J , Hautbergue GM et al (2014) . Brain, 137(7), 2040-2051.
• Cooper-Knock J, Walsh M, Higginbottom A, Highley JR, Bury J, Dickman M, Rattray M, Heath P, Wyles M, Ince P , Wharton S et al (2014) . Neurology, 82(10_supplement).
• Cooper-Knock J, Walsh M, Higginbottom A, Highley JR, Bury J, Dickman M, Rattray M, Heath P, Wyles M, Ince P , Wharton S et al (2014) . Neurology, 82(10_supplement).
• Yang D-J, Wang X-L, Ismail A, Ashman CJ, Valori CF, Wang G, Gao S, Higginbottom A, Ince PG, Azzouz M , Xu J et al (2014) . Cell Death and Disease, 5(2).
• Allen SP, Rajan S, Duffy L, Mortiboys H, Higginbottom A, Grierson AJ & Shaw PJ (2014) . Neurobiology of Aging, 35(6), 1499-1509.
• Da Costa MMJ, Allen CE, Higginbottom A, Ramesh T, Shaw PJ & McDermott CJ (2014) . Disease Models & Mechanisms, 7(1), 73-81.
• Cooper-Knock J, Higginbottom A, Connor-Robson N, Bayatti N, Bury JJ, Kirby J, Ninkina N, Buchman VL & Shaw PJ (2013) . Neurology, 81(19), 1719-1721.
• Nanou A, Higginbottom A, Valori CF, Wyles M, Ning K, Shaw P & Azzouz M (2013) . Molecular Therapy, 21(8), 1486-1496.
• Mead RJ, Higginbottom A, Allen SP, Kirby J, Bennett E, Barber SC, Heath PR, Coluccia A, Patel N, Gardner I , Brancale A et al (2013) . Free Radical Biology and Medicine, 61, 438-452.
• Buchman VL, Cooper-Knock J, Connor-Robson N, Higginbottom A, Kirby J, Razinskaya OD, Ninkina N & Shaw PJ (2013) . Molecular Neurodegeneration, 8(1), 12-12.
• Ning K, Drepper C, Valori CF, Wyles M, Ismail A, Higginbottom A, Herrmann T, Shaw PJ, Sendtner M & Azzouz M (2011) PTEN signalling in motor neuron disease (ALS & SMA). HUMAN GENE THERAPY, 22(10), A64-A64.
• Nanou A, Higginbottom A, Wyles M, Ning K, Shaw P & Azzouz M (2011) Gene therapy approaches to evaluate neuroprotection in experimental models of Amyotrophic Lateral Sclerosis. HUMAN GENE THERAPY, 22(10), A64-A64.
• Ferraiuolo L, Higginbottom A, Heath PR, Barber S, Greenald D, Kirby J & Shaw PJ (2011) . Brain, 134(9), 2627-2641.
• Ning K, Drepper C, Valori CF, Ahsan M, Wyles M, Higginbottom A, Herrmann T, Shaw P, Azzouz M & Sendtner M (2010) . Human Molecular Genetics, 19(16), 3159-3168.
• Parthasarathy V, Martin F, Higginbottom A, Murray H, Moseley GW, Read RC, Mal G, Hulme R, Monk PN & Partridge LJ (2009) . Immunology, 127(2), 237-248.
• Barber SC, Higginbottom A, Mead RJ, Barber S & Shaw PJ (2009) . Free Radical Biology and Medicine, 46(8), 1127-1138.
• Wright AJ, Higginbottom A, Philippe D, Upadhyay A, Bagby S, Read RC, Monk PN & Partridge LJ (2007) . Molecular Immunology, 44(10), 2507-2517.
• Ho S-H, Martin F, Higginbottom A, Partridge LJ, Parthasarathy V, Moseley GW, Lopez P, Cheng-Mayer C & Monk PN (2006) . Journal of Virology, 80(13), 6487-6496.
• Wood-Allum CA (2006) . Brain, 129(7), 1693-1709.
• Higginbottom A, Cain SA, Woodruff TM, Proctor LM, Madala PK, Tyndall JDA, Taylor SM, Fairlie DP & Monk PN (2005) . Journal of Biological Chemistry, 280(18), 17831-17840.
• Barreiro O, Yáñez-Mó M, Sala-Valdés M, Gutiérrez-López MD, Ovalle S, Higginbottom A, Monk PN, Cabañas C & Sánchez-Madrid F (2005) . Blood, 105(7), 2852-2861.
• Nishiura H, Tanase S, Shibuya Y, Futa N, Sakamoto T, Higginbottom A, Monk P, Zwirner JR & Yamamoto T (2005) . Journal of Cellular Biochemistry, 94(3), 540-553.
• Barreiro O, Yanez-Mo M, Sala-Valdes M, Dolores Gutierrez-Lopez M, Ovalle S, Higginbottom A, Monk PN, Cabanas C & Sanchez-Madrid F (2004) . Cardiovascular Pathology, 13(3), 108-108.
• Zhang J, Randall G, Higginbottom A, Monk P, Rice CM & McKeating JA (2004) . Journal of Virology, 78(3), 1448-1455.
• Muranova TA, Ruzheinikov SN, Higginbottom A, Clipson JA, Blackburn GM, Wentworth P, Datta A, Rice DW & Partridge LJ (2004) . Acta Crystallographica Section D Biological Crystallography, 60(1), 172-174.
• Higginbottom A, Takahashi Y, Bolling L, Coonrod SA, White JM, Partridge LJ & Monk PN (2003) . Biochemical and Biophysical Research Communications, 311(1), 208-214.
• Cain SA, Higginbottom A & Monk PN (2003) . Biochemical Pharmacology, 66(9), 1833-1840.
• Higginbottom A, Wilkinson I, McCullough B, Lanza F, Azorsa DO, Partridge LJ & Monk PN (2000) . Immunology, 99(4), 546-552.
• Higginbottom A, Quinn ER, Kuo C-C, Flint M, Wilson LH, Bianchi E, Nicosia A, Monk PN, McKeating JA & Levy S (2000) . Journal of Virology, 74(8), 3642-3649.
• Flint M, Maidens C, Loomis-Price LD, Shotton C, Dubuisson J, Monk P, Higginbottom A, Levy S & McKeating JA (1999) . Journal of Virology, 73(8), 6235-6244.
• Helm BA, Sayers I, Higginbottom A, Machado DC, Ling Y, Ahmad K, Padlan EA & Wilson APM (1996) . Journal of Biological Chemistry, 271(13), 7494-7500.
• Wiseman JP, Scarrott JM, Alves-Cruzeiro J, Saffari A, Böger C, Karyka E, Dawes E, Davies AK, Marchi PM, Graves E , Fernandes F et al () . EMBO Molecular Medicine.
• Cox LE, Ferraiuolo L, Goodall EF, Heath PR, Higginbottom A, Mortiboys H, Hollinger HC, Hartley JA, Brockington A, Burness CE , Morrison KE et al () . PLoS ONE, 5(3), e9872-e9872.
• Scola A-M, Higginbottom A, Partridge LJ, Reid RC, Woodruff T, Taylor SM, Fairlie DP & Monk PN () . Journal of Biological Chemistry, 282(6), 3664-3671.

Conference proceedings papers

• Alves-Cruzeiro JM, Karyka E, Bauer C, Coldicott I, Simon S, Hautbergue GM, Webster C, Myszczynska M, Higginbottom A, Ferraiuolo L & Azzouz M (2019) Gene editing as a potential therapeutic approach for ALS/FTD-associated with expanded C9ORF72. HUMAN GENE THERAPY, Vol. 30(8) (pp A22-A22)
• Allen SP, Hall B, Castelli L, Francis L, Woof R, Higginbottom A, Myszczynska M, Allen CF, Stopford MJ, Webster CP , De Vos K et al (2018) . Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1859 (pp e23-e23)
• Hewamadduma C, Grierson A, Higginbottom A & Shaw P (2015) . Journal of the Neurological Sciences, Vol. 357 (pp e49-e49)
• Beer A, Cooper-Knock J, Higginbottom A, Robin Highley J, Wharton SP, Milano A, Jones A, Al-Chalabi A, Kirby J & Shaw PJ (2014) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.130-e4)
• Simpson JE, Ince PG, Matthews F, Shaw PJ, Heath PR, Brayne C, Garwood C, Abdalla H, Higginbottom A & Wharton SB (2014) A neuronal DNA damage response is detected at low Braak stages and correlates with cognitive impairment in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 31-32)
• Ferraiuolo L, Higginbottom A, Heath PR, Barber S, Greenald D, Kirby J & Shaw PJ (2012) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(3) (pp e1.115-e1)
• Ning K, Drepper C, Ismail A, Valori CF, Wyles M, Higginbottom A, Herrmann T, Shaw P, Sharrack B, Sendtner M & Azzouz M (2010) PTEN Depletion Rescues the beta-Actin Deficit in Axonal Growth Cones in Motoneurons from a Mouse Model of Spinal Muscular Atrophy. NEUROLOGY, Vol. 74(9) (pp A489-A489)
• Nanou A, Higginbottom A, Valori C, Wyles M, Ning K, Shaw P & Azzouz M (2010) Oxidative Stress as Target for Neuroprotection in Experimental Models of Amyotrophic Lateral Sclerosis (ALS). NEUROLOGY, Vol. 74(9) (pp A436-A436)
• Madala PK, Stoermer M, Tyndall JDA, Monk PN, Higginbottom A & Fairlie DP (2008) COMP 264-Unraveling the mechanism of antagonism for human C5a receptor: Comparison of three structurally different antagonists. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 236
• Scola A-M, Higginbottom A, Partridge LJ & Monk PN (2007) . Molecular Immunology, Vol. 44(1-3) (pp 237-237)
• Monk PN, Higginbottom A, Madala PK, Tyndall JDA, Stoermer M & Fairlie DP (2006) Defining the ligand binding site on the human C5a receptor. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 231
• Wong CH, Higginbottom A, Monk P, Partridge LJ & Moore HD (2001) Inhibition of sperm-oolemma interactions by the extracellular domains of CD9 and CD81. ANDROLOGY IN THE 21ST CENTURY, SHORT COMMUNICATIONS (pp 565-572)
• Higginbottom A, Partridge LJ & Monk PN (1996) Identification of potential ligands for CD63 from random peptide libraries. IMMUNOLOGY, Vol. 89 (pp OM117-OM117)

Preprints

• Lin Y-H, Dodd JE, Cutillo L, Castelli LM, Mihaylov SR, Norris K, Higginbottom A, Walsh MJ, Cooper-Knock J, Highley JR , Granata I et al (2024) , Cold Spring Harbor Laboratory.
• Xia Z, Prescott E, Wareing H, Matuszyk M, Dakin H, Dimou E, Hidari E, Zhang Y, Lam J, Danial J , Leah T et al (2022) , Research Square Platform LLC.
• Moll T, Graves E, Urbanek A, Soni N, Ranganathan R, Higginbottom A, Wang S, Head BP, Cooper-Knock J & Shaw PJ (2022) , Cold Spring Harbor Laboratory.
• Xia Z, Prescott EE, Wareing HE, Matuszyk MM, Dakin H, Dimou E, Zuo E, Zhang YP, Lam JYL, Danial JSH , Leah T et al (2021) , Cold Spring Harbor Laboratory.
• Castelli LM, Sanchez-Martinez A, Lin Y-H, Upadhyay SK, Higginbottom A, Cooper-Knock J, Gül A, Walton A, Montmasson C, Cohen R , Bauer CS et al () , Cold Spring Harbor Laboratory.
• Hagai M-K, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Cohen N, Olender T, Moens T, Higginbottom A , Cooper-Knock J et al () , Cold Spring Harbor Laboratory.
• Marmor Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Olender T, Cohen N, Moens T, Higginbottom A , Cooper-Knock J et al () .
• Cooper-Knock J, Moll T, Ramesh T, Castelli L, Beer A, Robins H, Fox I, Niedermoser I, Van Damme P, Robberecht W , Hardiman O et al () .