Dr Emily Noël

School of Biosciences

Senior Lecturer

British Heart Foundation Intermediate Basic Science Research Fellow, Emily Noël
Profile picture of British Heart Foundation Intermediate Basic Science Research Fellow, Emily Noël
e.s.noel@sheffield.ac.uk

Full contact details

Dr Emily Noël
School of Biosciences
C21
Firth Court
Western Bank
΢Ȧ
S10 2TN
Profile

Brief career history

  • 2017-Present: British Heart Foundation Intermediate Basic Science Research Fellow, University of ΢Ȧ, UK
  • 2015-2017: Independent Research Fellow, University of ΢Ȧ, UK
  • 2009-2015: Postdoctoral Research Scientist, Bakkers Lab, Hubrecht Institute, Utrecht, NL
  • 2005-2009: PhD Student, Ober Lab, National Institute for Medical Research, London, UK
  • 2001-2004: BSc Biochemistry, University of Warwick
Research interests

The heart is a highly complex organ that forms very early during embryonic development from a simple linear tube. Problems with heart development often result in babies being born with congenital heart defects, a spectrum of structural heart malformations which affect around 1% of live births. Studying how hearts form when an organism is developing helps us better understand why this process sometimes goes wrong.

Our lab uses zebrafish to understand how the developing heart undergoes complex morphological rearrangements. We are particularly interested in how cells interact with their cellular neighbours or the extracellular matrix in different regions of the heart, and how these regionalised interactions support heart form and function as the embryo develops.

We use a variety of genetic and imaging techniques in zebrafish to link cellular processes/signalling, extracellular matrix composition, and heart morphology and function. These include establishing genetic models through targeted gene editing using CRISPR-Cas9, live light-sheet imaging of transgenic lines with fluorescent tissues or reporters, and quantitative image analyses.

Publications

Show: Featured publications All publications

Journal articles

  • Derrick CJ, Pollitt EJG, Sevilla Uruchurtu AS, Hussein F, Grierson AJ & Noël ES (2021) . Development. RIS download Bibtex download
  • Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, Noël ES & Serbanovic‐Canic J (2021) . British Journal of Pharmacology. RIS download Bibtex download
  • Derrick CJ & Noël ES (2021) . Development, 148(5), dev191320-dev191320. RIS download Bibtex download
  • Derrick CJ, Sánchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & Noël ES (2021) . Cardiovascular Research. RIS download Bibtex download
  • Noël ES & Bakkers J (2017) . eLife, 6. RIS download Bibtex download
  • Noël ES, Momenah TS, Al-Dagriri K, Al-Suwaid A, Al-Shahrani S, Jiang H, Willekers S, Oostveen YY, Chocron S, Postma AV , Bhuiyan ZA et al (2016) . Human Mutation, 37(2), 194-200. RIS download Bibtex download
  • Junker JP, Noël ES, Guryev V, Peterson KA, Shah G, Huisken J, McMahon AP, Berezikov E, Bakkers J & van Oudenaarden A (2014) . Cell, 159(3), 662-675. RIS download Bibtex download
  • Noël ES, Verhoeven M, Lagendijk AK, Tessadori F, Smith K, Choorapoikayil S, den Hertog J & Bakkers J (2013) . Nature Communications, 4(1). RIS download Bibtex download
  • Smith KA, Noël E, Thurlings I, Rehmann H, Chocron S & Bakkers J (2011) . PLoS Genetics, 7(9). RIS download Bibtex download

All publications

Journal articles

  • Sánchez-Posada J, Derrick CJ & Noël ES (2025) . PLOS Biology, 23(1). RIS download Bibtex download
  • Pollitt EJG, Sánchez-Posada J, Snashall CM, Derrick CJ & Noël ES (2024) . Development, 151(13), dev202482. RIS download Bibtex download
  • Derrick CJ, Pollitt EJG, Sevilla Uruchurtu AS, Hussein F, Grierson AJ & Noël ES (2021) . Development. RIS download Bibtex download
  • Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, Noël ES & Serbanovic‐Canic J (2021) . British Journal of Pharmacology. RIS download Bibtex download
  • Derrick CJ & Noël ES (2021) . Development, 148(5), dev191320-dev191320. RIS download Bibtex download
  • Derrick CJ, Sánchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & Noël ES (2021) . Cardiovascular Research. RIS download Bibtex download
  • Campbell K, Noël ES, Fletcher AG & Bulgakova NA (2020) . Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1809). RIS download Bibtex download
  • Noël ES & Bakkers J (2017) . eLife, 6. RIS download Bibtex download
  • Han MK, Hoijman E, Nöel E, Garric L, Bakkers J & de Rooij J (2016) . Biol Open, 5, 1461-1472. RIS download Bibtex download
  • Noël ES, Momenah TS, Al-Dagriri K, Al-Suwaid A, Al-Shahrani S, Jiang H, Willekers S, Oostveen YY, Chocron S, Postma AV , Bhuiyan ZA et al (2016) . Human Mutation, 37(2), 194-200. RIS download Bibtex download
  • Wu C-C, Kruse F, Vasudevarao MD, Junker JP, Zebrowski DC, Fischer K, Noël ES, Grün D, Berezikov E, Engel FB , van Oudenaarden A et al (2016) . Developmental Cell, 36(1), 36-49. RIS download Bibtex download
  • Tessadori F, Noël ES, Rens EG, Magliozzi R, Evers-van Gogh IJA, Guardavaccaro D, Merks RMH & Bakkers J (2015) . Developmental Cell, 32(5), 631-639. RIS download Bibtex download
  • Junker JP, Noël ES, Guryev V, Peterson KA, Shah G, Huisken J, McMahon AP, Berezikov E, Bakkers J & van Oudenaarden A (2014) . Cell, 159(3), 662-675. RIS download Bibtex download
  • Bonetti M, Paardekooper Overman J, Tessadori F, Noël E, Bakkers J & den Hertog J (2014) . Development, 141(9), 1961-1970. RIS download Bibtex download
  • Noël ES, Verhoeven M, Lagendijk AK, Tessadori F, Smith K, Choorapoikayil S, den Hertog J & Bakkers J (2013) . Nature Communications, 4(1). RIS download Bibtex download
  • Smith KA, Noël E, Thurlings I, Rehmann H, Chocron S & Bakkers J (2011) . PLoS Genetics, 7(9). RIS download Bibtex download
  • Mas JC, Noël ES & Ober EA (2011) , 401-428. RIS download Bibtex download
  • Noël ES, Reis MD, Arain Z & Ober EA (2010) . Gene Expression Patterns, 10(6), 237-243. RIS download Bibtex download
  • Noël ES, Casal-Sueiro A, Busch-Nentwich E, Verkade H, Dong PDS, Stemple DL & Ober EA (2008) . Developmental Biology, 322(2), 237-250. RIS download Bibtex download
  • Bowley G, Irving S, Hoefer I, Wilkinson R, Pasterkamp G, Darwish HMS, White S, Francis SE, Chico T, Noel E , Serbanovic-Canic J et al () . Scientific Reports, 14(1). RIS download Bibtex download

Chapters

  • Noël ES (2024) , Current Topics in Developmental Biology Elsevier RIS download Bibtex download

Conference proceedings papers

  • Sanchez-Posada J & Noel ES (2022) morphoHeart: A novel tool to capture, quantify and link 3D asymmetric heart morphogenesis with spatiotemporal extracellular matrix dynamics in zebrafish cardiac development. JOURNAL OF ANATOMY, Vol. 240(4) (pp 785-786) RIS download Bibtex download
  • Derrick CJ, Hussein F, Pollitt EJG & Noel ES (2021) Laminins regulate cardiac growth through restricting second heart field addition. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 102(2) (pp 126-126) RIS download Bibtex download
  • Carr PL, Jiang Z, Savage AM, Noël ES, Wilkinson RN & Lawrie A (2019) . C49. TICKET TO RIDE: EXPERIMENTAL MODELS OF PAH RIS download Bibtex download

Preprints

  • Jin Ji CC, Santos-Olivan D, Ramel M-C, Sanchez-Posada J, Paizakis P, Andrews TGR, Noel ES, Torres-Sanchez A & Priya R (2025) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Sánchez-Posada J & Noël ES (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Pollitt EJG, Derrick CJ, Sánchez-Posada J & Noël ES (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Derrick CJ, Pollitt EJG, Uruchurtu ASS, Hussein F & Noёl ES () . RIS download Bibtex download
  • Derrick CJ, Sánchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & Noël ES () , Cold Spring Harbor Laboratory. RIS download Bibtex download
Research group
Grants
  • British Heart Foundation
  • Academy of Medical Sciences/Wellcome Trust
  • Rosetrees Trust
Teaching activities
  • BMS110 Research Topics in Biomedicine
  • BMS242/3 Advanced Concepts in Developmental Biology
  • BMS356 Biomedical Technology & Drug Discovery
  • BMS336 Modelling Human Disease
  • BMS397 Laboratory Research Project
  • L4/MSc Dissertation and Laboratory Research Supervision